2016

The I.M. Rosenzweig Junior Investigator Award Winners​

The I.M. Rosenzweig Junior Investigator Award was established to encourage researchers to maintain and enhance their interest in PF research during the early stages of their academic career. 

Guoying Yu, PhD

Apr 20, 2021, 12:51 PM
Title : Guoying Yu, PhD
First Name : Guoying
Middle Name :
Last Name : Yu, PhD
Position :
University : Yale University
Proposal Title : “Thyroid hormone as a novel therapeutic agent in lung fibrosis”
Proposal Funder :
Dr. Guoying Yu got his BS, MS and PhD in the Henan Normal University, Yunnan University, and The Chinese Academy of Sciences in the Peoples' Republic of China respectively. He joined Dr. Kaminski' research group in 2006 in University of Pittsburgh and completed his research fellow training on pulmonary and moved to Yale in 2013. Dr. Yu has undertaken basic and translational investigations into idiopathic pulmonary fibrosis (IPF), a progressive, scarring of the alveolar parenchyma that ultimately leads to respiratory failure and death, charactering by the epithelial cell injury and unremitting accumulation of fibroblasts with unknown etiology without effective therapy. To gain insight into the pathogenesis of IPF, based on gene expression profiling of IPF lungs compared to normal controls, we focus on the genes that exhibited altered expression in IPF under the rationale that genes likely contribute to the development of pulmonary fibrosis. Currently I’m focusing on exploring the role and regulation of MMP19, miR-29 and thyroid hormone in human pulmonary fibrosis. We first investigated the role of thyroid hormone in pulmonary fibrosis and demonstrated that aerosolized TH delivery reversed bleomycin-induced fibrosis through restoration of AECs’ mitochondrial homeostasis and may represent an effective therapeutic strategy for patients with IPF.
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The Albert Rose Established Investigator Award Winners

Created to allow established investigators to explore novel, innovative areas of research, the Albert Rose Established Investigator Award provides critical support to the development of new projects, and enables the investigator to pursue additional funding through the National Institutes of Health or other agencies. Two $50,000 grants are awarded per annual cycle, disbursed over a two-year period.

Guoying Yu, PhD

Apr 20, 2021, 12:51 PM
Title : Guoying Yu, PhD
First Name : Guoying
Middle Name :
Last Name : Yu, PhD
Position :
University : Yale University
Proposal Title : “Thyroid hormone as a novel therapeutic agent in lung fibrosis”
Proposal Funder :
Dr. Guoying Yu got his BS, MS and PhD in the Henan Normal University, Yunnan University, and The Chinese Academy of Sciences in the Peoples' Republic of China respectively. He joined Dr. Kaminski' research group in 2006 in University of Pittsburgh and completed his research fellow training on pulmonary and moved to Yale in 2013. Dr. Yu has undertaken basic and translational investigations into idiopathic pulmonary fibrosis (IPF), a progressive, scarring of the alveolar parenchyma that ultimately leads to respiratory failure and death, charactering by the epithelial cell injury and unremitting accumulation of fibroblasts with unknown etiology without effective therapy. To gain insight into the pathogenesis of IPF, based on gene expression profiling of IPF lungs compared to normal controls, we focus on the genes that exhibited altered expression in IPF under the rationale that genes likely contribute to the development of pulmonary fibrosis. Currently I’m focusing on exploring the role and regulation of MMP19, miR-29 and thyroid hormone in human pulmonary fibrosis. We first investigated the role of thyroid hormone in pulmonary fibrosis and demonstrated that aerosolized TH delivery reversed bleomycin-induced fibrosis through restoration of AECs’ mitochondrial homeostasis and may represent an effective therapeutic strategy for patients with IPF.
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