Clinical Trials Education Center


About Clinical Trials

Clinical trials for pulmonary fibrosis treatment are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. These studies also may show which medical approaches work best for certain illnesses or groups of people. Clinical trials for pulmonary fibrosis treatment produce the best data available for health care decision making.

The purpose of clinical trials is research, so the studies follow strict scientific standards. These standards protect patients and help produce reliable study results.

Find a Clinical Trial

The PFF Clinical Trial Finder is a comprehensive list of clinical trials for pulmonary fibrosis related conditions.

Featured Trials


Systemic Sclerosis With and Without Interstitial Lung Disease


Study ID: NCT04948554
Trial Phase: Phase 1b
Intervention: Subcutaneous (SC) Injection
Sponsor: Acceleron Pharma Inc. (a wholly owned subsidiary of Merck Sharp and Dohme, a subsidiary of Merck & Co., Inc.)
Contact:; 1.888.577.8839

PFF Community Registry

Patients diagnosed with PF or ILD, Lung transplant recipients who have had PF or ILD, Caregivers and/or biological family members (parent, child, full/half sibling) of patients with PF or ILD — including those who have passed away (participants must be 18 or older and live in the U.S.) 

Study ID: NCT05382572
Sponsor: Pulmonary Fibrosis Foundation, University of Michigan
Contact: &

Interstitial Lung Disease & Obstructive Sleep Apnea


Study ID: NCT03901534
Intervention: Device - Auto-CPAP
Sponsor: Columbia University
Contact:; 212.342.0256

Idiopathic Pulmonary Fibrosis


Study ID: NCT05671835
Trial Phase: Phase 2
Intervention: Oral tablet
Sponsor: Tvardi Therapeutics


Drug Development Pipeline for PF & IPF

In the PF Drug Development Pipeline you can learn about the latest in drug development for PF-related conditions. Use the filters on the left-hand side to narrow results by study phase, intervention type, condition, and more.

Phases of Clinical Trials

Clinical trials investigate dosage, safety, efficacy and potential outcomes of drugs or treatments in disease-specific populations through controlled trials. There are typically three stages or phases of clinical trials that must be performed before a drug or treatment may be submitted to regulatory agencies (ie: U.S. Food & Drug Administration) for approval. Prior to commencing a clinical trial, a drug must have demonstrated safety and efficacy in a laboratory model.

Phase 1 Clinical Trials

Phase 1

Researchers test a new drug or treatment in a small group of people (usually 20-100 volunteers) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects. Doses start small and increase in different patient groups until the desired effect of the treatment is observed or side effects of the treatment become too severe.

Phase 2 Clinical Trials

Phase 2

The drug or treatment is given to a larger group of people (up to several hundred volunteers) to see if it is effective and to further evaluate its safety. Most Phase 2 studies have randomized control (placebo) groups and treatment groups. Most of these trials are “double-blind” which means that neither the patients nor the researchers know whether the patient is receiving the treatment or placebo.

Phase 3 Clinical Trials

Phase 3

The drug or treatment is given to large groups of people (several hundred to thousands of volunteers) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments (or placebo), and collect information that will allow the drug or treatment to be used safely. Phase 3 trials are also randomized and most are double-blind.

Phase 4 Clinical Trials

Phase 4

The drug or treatment has been FDA approved for marketing. These studies can include post-market requirement and commitment studies that are required of or agreed to by the study sponsor. Phase 4 trials gather additional information about a drug's safety, efficacy, or optimal use.

Clinical Trials FAQ's

What is a clinical trial?
What types of therapies are being studied?
What are the types of clinical trials?
What types of research are being performed in clinical trials for pulmonary fibrosis treatment?
What types of interventions are being used in clinical trials?